No doubt, our dermatologists are trying hard in order to find a better solution for coping with vitiligo. But in spite a lot of advancement in medical science; vitiligo is becoming a challenge for dermatologist as; it is extremely resistant to treat.

Although, PUVA is the main therapy for its treatment but it is a time-consuming, expensive, and only moderately effective therapy. Recently, in a vitiligo study, some isolated small vitiligo patches have been treated by punch grafts; Autologous cultured keratinocytes and melanocyte suction graft and blister epidermal grafts, in order to, varying the effectiveness of each treatment for vitiligo.

For this purpose, a thin epidermal sheet was taken from the buttocks by the application of Zimmer air dermatome. This 0.1mm thick sheet was then grafted onto superficially derma braded depigmented skin of 19 patients with vitiligo and 1 with piebaldism. After that this wound was remained cover with saline-soaked gauze for one week.

Finally, it came to know that, thin split-thickness skin grafts can be added to the list of other keratinocytes and melanocytes transfer procedures. Because, after 4 – 8 months, 64% of grafted sites achieved 95% to 100% repigmentation, 18% achieved 50% to 70% repigmentation, and 18% achieved 20% or less repigmentation. This technique had surprisingly, shown a successful rate of repigmentation.

But unfortunately, this therapy is only useful for people with piebaldism or stable vitiligo; as a complete repigmentation was only observed in them. The successful rate of this technique can be improved by combining it with PUVA or sun exposure.